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syndrome allgrove



english schema à venir stress oxydatif

This reaction is normal but here may bigger,

A essay of schematisation of the chemic shapes:

Ion : a atom or molecule won or lost one or many electrons, we can see two categories :
    Anion : a atom or molecule lost one or many electrons, so it's negative.
    Cation : a atom or molecule won one or many electrons, so it's positive.

It need catalyst for that oxygen to create a reactions with organical mater this catalists are a big enzymes

when a atom lost a electron we speak of redox reaction.



  • A oxydase is a enzyme catalyst a reaction of oxydo-réduction so this reaction use a dioxygen molecule (O2) as acceptor electron.

    The mitochondria is divided in 5 parts writted in roman numnbers : I,II,III,IV,V,
    each part fabrique is a chemic reaction to creat in part V energy or a molecule of ATP, it's explained below
    In -- the compartment I-- there is the reaction following :

    the gen MnSOD mitochondrial create isoenzyme SOD2 in part I of mitochondrie so the reaction following :
    O2-.

           NDAPH+H+ give NAD+ and export H+

       H+ = ion hydronium so lost is electron (or called proton hydrogen).
       NADP = nicotinamide adénine dinucléotide is a coenzyme oxydo-reduction.
       NADPH or NADPH2 or NADPH+H+ mechanism against oxydative stress.
       NADPH+H+ is used for biosynthese of fat acids of cholesterol
       SOD2 = Superoxide dismutase 2
      O 2-.= anion superoxyde

    In the compartment II there is reaction following :


       FADH2 → FAD

      FAD = Flavine adénine dinucléotide ( protein that contain flavine transportor of electrons, create by vitamine B2 ).


    in the compartiment III there is reaction following :

    this era III (paroi intermédiaire) of mitochondria product
    O2-., via SOD1.     exportation of H+
       SOD1 =
      O2-. = anion superoxyde (discovered in 1968) anion superoxyde interact with ions H+ ( because there is won a electron of him and so H lost 1 electron so H become a proton alone.

    In compartment IV there is reaction following :

    1/O2+2H-->H2O + export de H+ (so a oxydase process) H2O = water O2 = dioxigène or oxygen

    In compartment V there is reaction following :

        ATP ↓ - ADP+Pi

       Pi = inorganic phosphate
       ADP = adénosine diphosphate is a nucléotide

    inside the membrane of mitochondria there is the reaction following :

       O2.→SOD1→H2O2
      anion superoxyde = O2.-
      SuperOxydes Dismutases 1 = SOD (a enzyme antioxydante)
      H2O2 hydrogen peroxide

    remark de l'étude : SOD1 and SOD2 have studied on mice, it exist SOD3 too


    • So the cytosolic enzyme CuZnSOD by catalisat(?) give a reaction of anions superoxyde


    In mitochondria there si a reaction by a molecule called catalase ( or CAT ) water from peroxyde hydrogen as this : H2O2 →CAT→H2O ↓ And when the catalase down it's dangerous because peroxyde hydrogène H2O2,
    overwhelm catalase mitochondrial and catalase of peroxysome. peroxyde hydrogen give a reaction with iron ions called Fenton reaction

    Thz mitochondrial network create many ROS (reactive oxydatif species) so too stress oxydatif :
    this are Ros :
       O2-.= anion superoxyde
       OH- = anion hydroxyde
       CO3.- = anion carbonate
       NO2- = dioxyde d'azote
       ONOO- = ion peroxynitrite


    To summary : so we are two way to moment :
       1- what are molecules destroyed by ROS ^per organes.
       2- how to create a depletion of ros in some organes with nor risks for patients.
    then there was some researchs :
      before, we saw reaction of fth1 and aptx on DNA,
      on Cortisol on few next chapters.,
     on glucose don't transform enough ATP, the need of ATP by cell in a another chapter,
      on glutathion reductase(GSR) in a another chapter too.

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